研究方向
先心病、心脏保护与移植
我们研究先天性及重症心脏病中的心肌适应、损伤与修复，并将代谢和力学生物学发现转化为贯穿外科治疗、机械循环支持与心脏移植的保护、再生及医疗体系策略。
研究方向 01 · 先心病、心脏保护与移植
先心病、心脏保护与移植
我们研究先天性及重症心脏病中的心肌适应、损伤与修复，并将代谢和力学生物学发现转化为贯穿外科治疗、机械循环支持与心脏移植的保护、再生及医疗体系策略。
- 转化性心脏保护与先心病全生命周期管理
- 缺氧与心肌代谢适应
- 机械卸负荷、心肌恢复与再生
详细研究介绍
我们的研究聚焦发育阶段、缺氧、代谢状态与机械负荷如何共同塑造心肌适应、损伤与修复。在发绀型先天性心脏病（CHD）中，我们揭示青春期 HIF-1α 依赖性代谢适应受损的机制，并开展曲美他嗪等代谢靶向干预研究。在心脏移植与终末期心力衰竭领域，我们解析 CIRBP–DHODH 轴介导的铁死亡防御如何保护低温保存的老龄供心，以及机械卸负荷如何激活心外膜 NRG1–ERBB4–STAT3 信号和磷酸戊糖途径，促进心肌修复；同时探索肥胖相关胰岛素抵抗为何限制 LVAD 介导的心肌恢复，以及胰岛素增敏能否改善这一过程。
我们的研究还关注心外和治疗相关因素，包括肠道菌群来源的犬尿氨酸，以及急性髓系白血病治疗中 IL-1α 介导的心脏毒性。通过整合机制研究、多中心临床试验、群体研究与先心病区域协作医疗，我们致力于将分子发现连接至外科治疗、机械循环支持、移植与长期随访，保护心肌功能、拓展治疗机会，并改善儿童及成人心脏病患者公平的全生命周期结局。
本方向论文23
- Mechanical unloading promotes adult cardiomyocyte proliferation through epicardial NRG1-ERBB4 signaling
Nature cardiovascular research2026先心病、心脏保护与移植
- Midterm outcomes of coronary artery bypass grafting for Kawasaki disease in children: A multicenter retrospective study in China
Chinese medical journal2026先心病、心脏保护与移植
- Global Burden of Pediatric Cardiovascular Diseases of Congenital and Non-Congenital Trends from 1992 to 2021
Communications medicine2026先心病、心脏保护与移植
- Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model
The Journal of clinical investigation2024先心病、心脏保护与移植
- Rescue of cardiac dysfunction during chemotherapy in acute myeloid leukaemia by blocking IL-1α
European heart journal2024先心病、心脏保护与移植
- Current status and future directions in pediatric ventricular assist device
Heart failure reviews2024先心病、心脏保护与移植
- A surgical mouse model of neonatal right ventricular outflow tract obstruction by pulmonary artery banding
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2024先心病、心脏保护与移植
- Worldwide trends in mortality for hypertensive heart disease from 1990 to 2019 with projection to 2034: data from the Global Burden of Disease 2019 study
European journal of preventive cardiology2024先心病、心脏保护与移植
- Targeting gut microbiota-derived kynurenine to predict and protect the remodeling of the pressure-overloaded young heart
Science advances2023先心病、心脏保护与移植
- Improving long-term care and outcomes of congenital heart disease: fulfilling the promise of a healthy life
The Lancet. Child & adolescent health2023先心病、心脏保护与移植
- Analysis and prediction of research hotspots and trends in pediatric medicine from 2,580,642 studies published between 1940 and 2021
World journal of pediatrics : WJP2023先心病、心脏保护与移植
- Infection with the SARS-CoV-2 Omicron variant in children with congenital heart disease: A case series study during Shanghai epidemic
Frontiers in cardiovascular medicine2022先心病、心脏保护与移植
- Adaptive Cardiac Metabolism Under Chronic Hypoxia: Mechanism and Clinical Implications
Frontiers in cell and developmental biology2021先心病、心脏保护与移植
- Impact of early Coronavirus Disease 2019 pandemic on pediatric cardiac surgery in China
The Journal of thoracic and cardiovascular surgery2021先心病、心脏保护与移植
- Neonatal surgical outcomes after prenatal diagnosis of complex congenital heart disease: experiences of a perinatal integrated diagnosis and treatment program
World journal of pediatrics : WJP2020先心病、心脏保护与移植
- Transcriptional Profile Alteration of Peripheral Blood in Chronic Hypoxia
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih2020先心病、心脏保护与移植
- Addressing the rising burden of congenital heart disease in China
The Lancet. Child & adolescent health2020先心病、心脏保护与移植
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