Welcome to Zhang Lab

“Truly wonderful, the mind of a child is.”

— Yoda · Star Wars

Research

Research Directions

CHD & Cardioprotection & Transplantation

We investigate myocardial adaptation, injury and recovery across congenital and advanced heart disease, translating metabolic and mechanobiological discoveries into cardioprotective, regenerative and systems-of-care strategies spanning surgery, mechanical support and transplantation.

Translational cardioprotection and lifelong CHD careHypoxia and myocardial metabolic adaptation

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Pulmonary Hypertension

We combine multi-omics, disease models, artificial intelligence and clinical investigation to define pulmonary vascular disease and right ventricular failure, and to develop mechanism-based targets, quantitative diagnostics and accessible interventions for children with pulmonary hypertension.

Pulmonary vascular and right ventricular remodelingReverse Potts shunt and rescue support

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Tissue Engineering

We are committed to advancing cardiovascular regenerative medicine, focusing on the development of innovative cardiac patches for injury repair and anti-adhesion, advanced heart valves, and novel cardiovascular stents, aiming to restore cardiac function, improve hemodynamics, and ultimately enhance the prognosis.

Cardiac patches for repair & anti-adhesionNext-generation heart valves

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Publications

Latest Publications

All Publications

Mechanical unloading promotes adult cardiomyocyte proliferation through epicardial NRG1-ERBB4 signaling
Nature cardiovascular research2026CHD & Cardioprotection & Transplantation
SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension
Journal of molecular and cellular cardiology2026Pulmonary Hypertension
Advances in the pathogenesis and clinical management of pulmonary hypertension
Medical review2026Pulmonary Hypertension
Midterm outcomes of coronary artery bypass grafting for Kawasaki disease in children: A multicenter retrospective study in China
Chinese medical journal2026CHD & Cardioprotection & Transplantation

News & Events

The lab team at the World Congress of Pediatric Cardiology & Cardiac Surgery

December 4, 2025

The Lab Attends the 9th World Congress of Pediatric Cardiology & Cardiac Surgery (WCPCCS)

Lab members attended the 9th World Congress of Pediatric Cardiology & Cardiac Surgery, exchanging frontier progress in congenital heart disease care and research with peers worldwide.

Prof. Hao Zhang presenting at the Xijing International Forum on fetal cardiac malformations

November 8, 2025

Prof. Hao Zhang Speaks at the Xijing International Forum on Diagnosis and Intervention of Fetal Cardiac Malformations

The forum focused on prenatal diagnosis, imaging assessment and postnatal intervention of fetal cardiac malformations. Prof. Hao Zhang shared the lab’s progress and insights in fetal cardiovascular care.

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Together for Children’s Cardiovascular Health

We welcome partners in clinical care, research and industry to collaborate with us in advancing the diagnosis, treatment and research of pediatric cardiovascular disease.